Fomepizole is a medication used to treat poisoning from methanol or ethylene glycol (antifreeze). It works by inhibiting the enzyme responsible for breaking down these toxic substances, allowing them to be excreted from the body.
The dose of fomepizole depends on the patient’s weight and the severity of their poisoning. It is typically given intravenously, either in a hospital or emergency setting. The usual dose is a loading dose of 15 mg/kg followed by 10 mg/kg every 12 hours for up to four doses.
Like all medications, fomepizole can cause side effects. The most common side effects include headache, nausea, dizziness, and a metallic taste in the mouth. More serious side effects, such as seizures or low blood pressure, are rare but can occur.
Fomepizole is sold under the brand name Antizol in the United States. It is also available as a generic medication.