Protamine sulfate is a medication primarily used to reverse the effects of heparin, a blood thinner, which is often used during surgeries or other medical procedures. It works by binding to heparin, which allows the body to break it down and eliminate it more quickly. Protamine sulfate can also be used to reverse the anticoagulant effects of low molecular weight heparin.
Some brand names for protamine sulfate include Protamine Sulfate Injection, Nabi-HB, and Pronativ. The dose of protamine sulfate needed will depend on several factors, including the amount of heparin given and the patient’s weight. The usual dose for heparin reversal is 1 mg of protamine sulfate for every 100 units of heparin given. However, the dose may be adjusted based on the patient’s individual needs. It is important to follow the dosage instructions provided by a healthcare professional.